Antibacterial agents: Selected publications

von Nussbaum F, Anlauf S, Benet-Buchholz J, Häbich D, Köbberling J, Musza L, Telser J, Rübsamen-Waigmann H, Brunner NA.
Structure and total synthesis of lysobactin (katanosin B). Angew Chem Int Ed Engl. 2007;46(45):8548-52.

Hinzen B, Raddatz S, Paulsen H, Lampe T, Schumacher A, Häbich D, Hellwig V, Benet-Buchholz J, Endermann R, Labischinski H, Brötz-Oesterhelt H.
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. ChemMedChem. 2006 Jul;1(7):689-93.

Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H.
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Erratum in: Nat med. 2005 Dec;11(12):1361. Comment in:  Nature med. 2005 Oct;11(10):1045-6.

Freiberg C, Fischer HP, Brunner NA.
Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants. Antimicrob Agents Chemother. 2005 Feb;49(2):749-59.

Freiberg C, Brunner NA, Schiffer G, Lampe T, Pohlmann J, Brands M, Raabe M, Häbich D, Ziegelbauer K.
Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity. J Biol Chem. 2004 Jun 18;279(25):26066-73. Epub 2004 Apr 2.

Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, Bauser M, Pohlmann J, Brands M, Ziegelbauer K, Haebich D, Eymann C, Brötz-Oesterhelt H.
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. Antimicrob Agents Chemother. 2004 Feb;48(2):525-32.

Brötz-Oesterhelt H, Knezevic I, Bartel S, Lampe T, Warnecke-Eberz U, Ziegelbauer K, Häbich D, Labischinski H.
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones. J Biol Chem. 2003 Oct 10;278(41):39435-42. Epub 2003 Jul 15.

Bandow JE, Brötz H, Leichert LI, Labischinski H, Hecker M.
Proteomic approach to understanding antibiotic action. Antimicrob Agents Chemother. 2003 Mar;47(3):948-55.