AIC649 - Proprietary Immune Modulator and Potential Cure for Chronic Hepatitis B Infection

AIC649 is a proprietary inactivated parapox virus (iPPVO). It induces a natural, self-limiting immune response, enhancing appropriate immune responses against unrelated viruses. As a novel biological immune modulator, AIC649 has been conceived as curative treatment for HBV. Results from the woodchuck model provide strong evidence for functional cure of HBV infection.
AIC649 is being developed as first-line therapy in combination with standard of care for patients chronically infected with the HBV. AiCuris is currently testing AIC649 in a Phase I study in chronic HBV patients.
In addition to its antiviral activity, AIC649 also prevents and ameliorates fibrosis and has potent antitumor properties as demonstrated by results obtained in several in-vivo cancer models.
AIC649 is currently open for partnering.
Interested in paving the way towards HBV functional cure? Please contact: business(at)

If you have further questions regarding partnering of our projects please contact:

Business Development & Alliance

AiCuris Anti-infective Cures GmbH
Friedrich-Ebert-Str. 475
42117 Wuppertal

Phone: +49 (0)202 317 63 - 0
Fax: +49 (0)202 317 63 - 1177
E-Mail: business(at)